FIGURE 6.

Clinical plasma concentrations of doxorubicin in on‐treatment children between 11 and 56 weeks old (dots) after administration of a doxorubicin infusion with a duration between 0.07 and 4.5 h. Lines are simulations in infant of 0.25, 0.5 and 1 years old with the worst‐case parameter model after a doxorubicin infusion of 0.7 (red), 1 (green), and 1.4 mg/kg with a duration of 0.5 h. Note that infusion duration is shorter for some of the simulations than for some of the clinical plasma concentrations and that the worst‐case parameters in the model are absorption related and therefore have minimal effect on exposure after i.v. administration.