TABLE 5.
Test scenarios evaluating covariate effects on final model parameters.
| Parameter | Covariate applied to parameter | Individual patient covariate value | Excel calculated covariate effect | Parameter modulation effect |
|---|---|---|---|---|
| Test 1 (Reference values) | ||||
| CL | CLcrN | 100 | 4.58 | 1 |
| V | BW | 70 | 107.1 | 70 |
| Test 2A | ||||
| CL | CLcrN | 100 | 4.58 | 1 |
| V | BW | 35 a | 53.55 | 35 |
| Test 2B | ||||
| CL | CLcrN | 100 | 4.58 | 1 |
| V | BW | 140 a | 214.2 | 140 |
| Test 3A | ||||
| CL | CLcrN | 50 a | 2.29 | 0.5 |
| V | BW | 70 | 107.1 | 70 |
| Test 3B | ||||
| CL | CLcrN | 150 a | 6.87 | 1.5 |
| V | BW | 70 | 107.1 | 70 |
Abbreviations: BW, body weight; CL, clearance; CLcrN, creatinine clearance normalized to body surface area; V, volume of distribution.
a
Indicates individual patient value differs from the reference patient value.