Table 4.
Total number of lipophilic alkaloid families found in amphibian skins and chemical features useful for annotation process. Chemical features obtained from (Daly et al. 1993, 2005, 2009; Saporito et al. 2012)
| Class Subclass | # * | Type of alkaloid | Lower molecular mass (m/z) | Higher molecular mass (m/z) | Principal ions by MS |
|---|---|---|---|---|---|
| 1,4- disubstituted quinolizidines | 22 | Bicyclic | 207 | 295 | 110 and 84 |
| 3,5-disubstituted indolizidines | 23 | Bicyclic | 167 | 275 | 124 |
| 3,5- disubstituted pyrrolizidines | 23 | Bicyclic | 167 | 267 | Variable |
| 4,6- disubstituted quinolizidines | 6 | Bicyclic | 195 | 279 | Variable |
| 5,6,8- trisubstituted indolizidines | 76 | Bicyclic | 193 | 353 | 70 and 110 or 124 or 138… |
| 5,8- disubstituted indolizidines | 77 | Bicyclic | 167 | 297 | 138 or 152 or 180 or 96 |
| 5,8- disubstituted dehydroindolizidines | 32 | Bicyclic | 179 | 275 | 120 and 136 and 134 or 150 and 148 or 164 or 162 |
| Decahydroquinolines | 32 | Bicyclic | 181 | 293 | 152 or 168 or 341 |
| Decahydroquinolines dimers | 6 | Bicyclic | 380 | 400 | 341 or 191 and 193 |
| N-Methyldecahydroquinolines | 5 | Bicyclic | 233 | 283 | Variable |
| Epiquinamide | 1 | Bicyclic | 196 | 196 | 137 |
| Histrionicotoxins | 16 | Bicyclic | 291 | 235 | 96 or 250 |
| Homopumiliotoxins | 18 | Bicyclic | 223 | 353 | 180 and 84 or 207 |
| Desmethylhomopumiliotoxins | 4 | Bicyclic | 229 | 339 | 166 and 84 |
| Deoxyhomopumiliotoxins | 3 | Bicyclic | 193 | 251 | 164 and 84 |
| Lehmizidines | 9 | Bicyclic | 275 | 293 | Variable |
| Other izidines | 68 | Bicyclic | 191 | 295 | Variable |
| Pumiliotoxins | 39 | Bicyclic | 209 | 353 | 166 or 70 or 193 |
| Allopumiliotoxins | 23 | Bicyclic | 225 | 357 | 70 or 209 |
| Deoxipumiliotoxins | 15 | Bicyclic | 193 | 309 | 150 |
| Dehydrodesmethylpumiliotoxins | 4 | Bicyclic | 221 | 251 | 162 and 160 |
| Desmethylpumiliotoxins | 3 | Bicyclic | 249 | 265 | 152 and 170 |
| Batrachotoxins | 6 | Steroidal | 399 | 568 | 399 |
| Indolic alkaloids | 2 | Indolic | 346 | 346 | 346 and 173 |
| Pseudophrynamines | 16 | Indolic | 242 | 528 | Variable |
| Piperidines | 29 | Monocyclic | 183 | 269 | 98 or 114 |
| Pyrrolidines | 10 | Monocyclic | 183 | 279 | Variable |
| Epibatidines | 4 | Pyridinic | 208/210 | 308/310 | 69 or 82 and 56 and 167 |
| Pyridinic alkaloids | 3 | Pyridinic | 162 | 239 | 84 |
| Cyclopentaquinazolines | 9 | Tricyclic | 235 | 279 | 211 |
| Gephyrotoxins | 2 | Tricyclic | 287 | 289 | Variable |
| Spiropyrrolizidines | 7 | Tricyclic | 151 | 254 | 112 or 126 or 142 |
| Tricyclics | 66 | Tricyclic | 191 | 333 | Variable |
| Alkaloids without classification | 192 | Variable | 151 | 434 | 58 or 67 or 70 or 82 or 84 or 86 or 110 or 116 or 118 or 120 or 122 |
| Total number of alkaloids | 851 |
*The number reported for each class/subclass is until of 2012