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. 2023 Nov 8;23(8):4665–4672. doi: 10.1007/s10238-023-01249-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Box plot analysis and optimal cutoff value analysis for NKCC4 in this cohort. A Box plot analysis of the NKCC4 in DLBCL patients who were dead or remained survival until the last follow-up. The absolute NKCC4 was significantly higher in survival patients than those who died during the study period (p < 0.0001). B Pearson correlation analysis demonstrated the positive correlation between NKCC4 and total lymphocyte count after four cycles of R-CHOP treatment (exclude data with large discrepancies). C ROC curve analysis identified NKCC4 as a biomarker for death after R-CHOP therapy. Area under the ROC curve analysis suggested a cutoff value of 135 cells/μl (AUC = 0.67)