Table 1.

Patient baseline characteristics

Characteristic	Total (n = 261)
Age
Median (range)	64 (27–88)
Age > 60, n (%)	157 (60)
Sex, n (%)
Female	161 (62)
Male	100 (38)
ECOG score
0–1	148 (57)
2–3	113 (43)
Extranodal site, n (%)
Yes	160 (61)
No	101 (39)
Bulky disease, n (%) (≥ 10 cm)
Yes	24 (9)
No	237 (91)
Stage, n (%)
I	36 (14)
II	57 (22)
III	75 (29)
IV	93 (34)
Elevated LDH, n (%)
Yes	124 (48)
No	137 (42)
Bone marrow involvement
Yes	33 (13)
No	228 (87)
IPI score
0–2	132 (51)
3–5	129 (49)
Subtype n (%)
GCB	78 (30)
Non-GCB	183 (70)
NKCC4, n (%)
> 135 cell/μl	111 (43)
< 135 cell/μl	150 (57)

ECOG Eastern Cooperative Oncology Group; LDH serum lactate dehydrogenase; IPI International Prognostic Index; GCB germinal center B cell-like; NKCC4 absolute peripheral blood NK cell count after four cycles of R-CHOP