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. 2023 Dec 16;13:22386. doi: 10.1038/s41598-023-49679-w

Figure 3.

Figure 3

Functional features with significant differences between Control and T2DM groups in the study cohort. (A) 32 KEGG modules significantly enriched in differentially abundant KO groups between Control and T2DM groups (** FDR < 0.05, *P value < 0.05; Gene Set Enrichment Analyses). The mean beta coefficients of module KOs abundances between control and T2DM individuals are represented as an indicator of enrichment direction (linear regression of log-transformed KO abundances by disease state adjusted by age and resequencing status; modules enriched in the T2DM group = mean beta coefficients of KO groups in Controls vs. T2DM > 0; modules enriched in the Control group = mean beta coefficients of KO groups in Controls vs. T2DM < 0). (B) Same as (A) for 6 Gut Metabolic Modules (GMMs) significantly enriched in differentially abundant KO groups between Control and T2DM groups (**FDR < 0.05; Gene Set Enrichment Analyses).