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. 2023 Dec 16;9(1):87. doi: 10.1038/s41537-023-00422-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Scatterplot represents the relationship between PLS2 score and case–control FNC differences. Each point denotes a tissue sample. B Ranked PLS2 genes based on Z-score. C Cell type-specific expression analyses using the PLS2+ gene list. D Cell type-specific expression analyses using the PLS2- gene list. Colored cell types represent significance after multiple testing correction. The sizes of the hexagons denote cell-type specificity across different specificity index probability (pSI) statistic thresholds ranging from 0.05 to 1e-4. The outer hexagons correspond to the least specific test for a cell type (pSI threshold = 0.05), whereas the innermost hexagon reflects the most specific test for a cell type (pSI threshold = 1e-4). FNC functional network centrality, PLS partial least squares.