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. 2023 Dec 16;13:22406. doi: 10.1038/s41598-023-49440-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Immunoblotting of ALDOA and PKM indicate the presence of full-length proteins in CSF. (A) Western blot bands at the expected sizes of 60 kDa for PKM and at 40 kDa for ALDOA indicate the presence full length protein. Normalized band intensities of ALDOA and PKM follow similar AD enrichment pattern across groups as the protein level quantifications for ALDOA and PKM (*: Post-hoc Dunn test p < 0.05). Original blots are presented in Supplementary Fig. 4A. (B) Protein level MS-intensity of both ALDOA and PKM are significantly correlated with the normalized western blot band intensity. This positive correlation indicates the presence of full-length ALDOA and PKM proteins in CSF.