Table 1.
Diagnosis | N | Age | Gender | Aβ42/40 ratio | pTau(181) | tTau | |
---|---|---|---|---|---|---|---|
Mean (SD) | Range | Females N (%) | Mean (SD) | Mean (SD) | Mean (SD) | ||
CU | 68 | 64.2 (7.53) | 55–85 | 38 (55.9) | 0.112 (0.015) | 29.16 (10.61) | 212.4 (74.2) |
MCI-AD | 95 | 70.7 (7.33) | 56–86 | 44 (46.3) | 0.052 (0.016) *,†,$ | 89.10 (46.55) *,†,#,$ | 442.6 (202.5)*,†,#,$ |
DEM-AD | 72 | 71.5 (9.26) | 56–93 | 33 (45.8) | 0.053 (0.015)*,†,$ | 98.76 (50.91) *,†,#,$ | 470.3 (255.1)*,†,#,$ |
MCI-other | 77 | 68.2 (7.59) | 55–84 | 27 (35.1) | 0.131 (0.197) | 28.03 (18.48) | 220.0 (115.1) |
DEM-other | 23 | 70.5 (9.51) | 57–89 | 9 (39.1) | 0.112 (0.023) | 30.94 (21.10) | 198.8 (89.8) |
NPH | 57 | 75.0 (7.73) | 57–94 | 20 (35.1) | 0.102 (0.027) | 29.00 (21.66) | 204.6 (114.1) |
CU = Cognitively unimpaired and includes 20 with no other specified neurological disorders, 18 patients evaluated for immune disease, 9 patients with other non-dementing neurodegenerative diseases, 6 patients with vascular disease, 5 with demyelinating disease, 4 patients with headache, 3 patients with psychiatric disease, 3 patients with idiopathic intracranial hypertension, and 1 patient with neoplasm, MCI-AD = mild cognitive impairment due to Alzheimer’s disease; DEM-AD = dementia due to Alzheimer’s disease, MCI-other = mild cognitive impairment due to other non-AD causes, DEM-other = dementia due to other non-AD causes, NPH = normal pressure hydrocephalus. Only MCI-AD and DEM-AD subjects had CSF AD biomarkers with low Aβ42/40 indicating AD. All others had normal Aβ42/40 above diagnostic threshold value. Group differences were assessed with ANOVA and p-values indicate results from post-hoc Tukey test.
* = significantly different compared to CU (p < 0.05).
† = significantly different compared to MCI-other (p < 0.05).
# = significantly different compared to DEM-other (p < 0.05).
$ = significantly different compared to NPH (p < 0.05).