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. 2023 Dec 16;6:1272. doi: 10.1038/s42003-023-05655-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The chemical structure of C7683 is presented. C7683 stabilized (a) TKBD-LHR-RING and (b) full-length Cbl-b at 3 μM with ΔT_m values of 10 ± 0.4 and 12 ± 0.2 °C, respectively. The stabilization effect of C7683 was concentration dependent (c, d) for both constructs at concentrations ranging from 0.01 to 100 µM. All experiments were performed in triplicates (n = 3).