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. 2023 Aug 18;12:107. Originally published 2023 Jan 27. [Version 2] doi: 10.12688/f1000research.126059.2

Figure 2. Mechanism of action of biochanin-A in breast cancer.

Figure 2.

Biochanin-A dephosphorylates HER-2 receptor and MAPK or ERK1/2 causing blockade of cancer cell development, growth, metastasis, and mitogenesis. Biochanin-A inhibits Akt phosphorylation thereby downregulates mTOR signals and disrupts the cell cycle. It inhibits NFkB and interrupts transcription. It inhibits topoisomerase-ll and DNA replication ( Azuma et al., 1995; Gotoh et al., 1998; Sehdev, Lai and Bhushan, 2009; Bhardwaj et al., 2014).