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. 2023 Dec 16;24:317. doi: 10.1186/s12931-023-02630-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Sampling collection data through time and lung function response to ETI treatment among participants. A Schematic of longitudinal samples collected for this study. Each black line represents a sample collection day. Black arrowheads represent the day in which subjects started on ETI treatment. B Lung function variation for highest ppFEV1% predicted pre- and post-ETI treatment per subject on each group and the absolute delta variation in the change in ppFEV1% predicted per subject post-ETI treatment within each group. The significance was determined through the DM t-test and Welch’s t-test respectively. C Lung function as ppFEV1% predicted of individual subjects through time (days) before and after ETI. Colors represent the treatment status (pre- and post-ETI) in which lung function was recorded and its corresponding significance (T-test) between the two different periods