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. 2023 Dec 16;24:317. doi: 10.1186/s12931-023-02630-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Metabolome dynamics of subjects on ETI therapy through time of sampling. A Bar plots representing the metabolome’s normalized peak area of longitudinally collected sputum samples from seven subjects on ETI. The sample collection time point (beginning and end of days) per subject is displayed, while gaps across sampling are not shown. B Line plots represent the GLP:small peptide log-ratios. C Molecular networking displaying Pseudomonas-like molecules from sputum samples of subjects on ETI. Nodes in yellow denote those molecular features annotated by GNPS. D Scatter plot representing the molecular dynamics between selected Pseudomonas metabolites, the time in days since subjects 011 and 015 started on ETI, while the size represents the relative abundance of Pseudomonas at the time of sampling over time