Table 3.
Summary of treatment response in the study population: Comparison between patients treated with combination chemotherapy and immunotherapy versus chemotherapy alone
| Chemotherapy plus ICI | Overall | Normal CRP | Elevated CRP | P | |
| n = 105 | n = 42 | n = 63 | |||
| Best Response (%) | CR | 2 (2) | 2 (4) | 0 (0) | 0.023 |
| PR | 60 (57) | 28 (60) | 32 (51) | ||
| SD | 34 (32) | 12 (29) | 22(35) | ||
| PD | 9 (9) | 0 (0) | 9 (14) | ||
| Objective Response Rate (%) | CR + PR | 62 (59) | 30 (71) | 32 (51) | 0.035 |
| Disease Control Rate (%) | CR + PR + SD | 96 (91) | 42 (100) | 54 (86) | 0.015 |
| Chemotherapy alone | Overall | Normal CRP | Elevated CRP | P | |
| n = 140 | n = 42 | n = 98 | |||
| Best Response (%) | CR | 1 (1) | 1 (2) | 0 (0) | 0.312 |
| PR | 59 (42) | 20 (48) | 39 (40) | ||
| SD | 66 (47) | 20 (48) | 46 (47) | ||
| PD | 14 (10) | 1 (2) | 13 (13) | ||
| Objective Response Rate (%) | CR + PR | 60 (43) | 21 (50) | 39 (40) | 0.322 |
| Disease Control Rate (%) | CR + PR + SD | 126 (90) | 41 (98) | 85 (87) | 0.096 |
Abbreviations: CR complete response, PR partial response, SD stable disease, PD progressive disease, ICI immune checkpoint inhibitor, n number of patients
Bold values indicate p < 0.05, signifying statistical significance