Table 3.
Pooled HRs of overall survival of patients with increased SNHG expression
| No. of studies | No. of patients | Pooled HR (95% CI) | Heterogeneity | |||
|---|---|---|---|---|---|---|
| Fixed | Random | I2(%) | P-value | |||
| OS | 30 | 1748 | 1.890 (1.595–2.185) | 1.89 (1.595–2.185) | 0 | 0.98 |
| Cut-off value | ||||||
| Median | 12 | 644 | 1.643 (1.262–2.024) | 1.643 (1.262–2.024) | 0 | 0.847 |
| Mean | 17 | 1062 | 2.262 (1.790–2.734) | 2.262 (1.790–2.734) | 0 | 0.995 |
| Not reported | 1 | 42 | 2.160 (-0.665–4.985) | 2.160 (-0.665–4.985) | - | - |
| Analysis method | ||||||
| Multivariate analysis | 3 | 247 | 2.793 (1.631–3.955) | 2.793 (1.631–3.955) | 0 | 0.734 |
| Univariate analysis | 27 | 1501 | 1.828 (1.523–2.133) | 1.828 (1.523–2.133) | 0 | 0.988 |
| Number of patients | ||||||
| Less than 100 | 27 | 1382 | 2.159 (1.783–2.534) | 2.159 (1.783–2.534) | 0 | 1 |
| Not less than 100 | 3 | 366 | 1.457 (0.980–1.933) | 1.873 (0.764–2.982) | 48.6 | 0.143 |
| Follow-up (month) | ||||||
| Not less than 60 month | 22 | 1319 | 1.819 (1.503–2.135) | 1.819 (1.503–2.135) | 0 | 0.962 |
| Less than 60 month | 8 | 429 | 2.373 (1.550–3.197) | 2.373 (1.550–3.197) | 0 | 0.885 |
| NOS score | ||||||
| 9 | 3 | 247 | 2.793 (1.631–3.955) | 2.793 (1.631–3.955) | 0 | 0.734 |
| Less than 9 | 27 | 1501 | 1.828 (1.523–2.133) | 1.828 (1.523–2.133) | 0 | 0.988 |
OS Overall survival, Random Random effects, Fixed Fixed effects, directly HR was extracted directly from the primary articles, indirectly HR was extracted indirectly from the primary articles, CI Confidence interval