Table 4.
Pool effects of clinicopathologic characteristics in lung cancer patients with abnormal SNHG expression
| Clinicopathologic characteristics | No. of studies | No. of patients | Odds ratio (95% CI) | P | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
| Fixed | Random | I2(%) | P-value | ||||
| Age | 28 | 1619 | 1.045 (0.879–1.242) | 1.045 (0.879–1.243) | 0.62 | 0 | 1 |
| Gender | 28 | 1584 | 0.970 (0.806–1.166) | 0.970 (0.806–1.168) | 0.744 | 0 | 1 |
| TNM (III+IV vs. I+II) | 28 | 1589 | 1.509 (1.267–1.799) | 1.521 (1.220–1.897) | < 0.0001 | 30.3 | 0.064 |
| SNHG expression | |||||||
| High SNHG expression | 26 | 1484 | 1.650 (1.374–1.980) | 1.654 (1.366–2.003) | < 0.0001 | 4.2 | 0.402 |
| Low SNHG expression | 2 | 105 | 0.424 (0.207–0.867) | 0.426 (0.208–0.872) | 0.019 | 0 | 0.684 |
| NOS score | |||||||
| 9 | 2 | 184 | 2.043 (1.215–3.435) | 2.039 (1.212–3.432) | 0.007 | 0 | 0.616 |
| Less than 9 | 26 | 1405 | 1.451 (1.204–1.748) | 1.472 (1.160–1.868) | < 0.0001 | 32.5 | 0.054 |
| LNM (present vs. absent) | 29 | 1662 | 1.540 (1.298–1.828) | 1.551 (1.257–1.914) | < 0.0001 | 27.1 | 0.091 |
| SNHG expression | |||||||
| High SNHG expression | 27 | 1557 | 1.681 (1.406–2.008) | 1.666 (1.389–1.997) | < 0.0001 | 0 | 0.514 |
| Low SNHG expression | 2 | 105 | 0.435 (0.216–0.876) | 0.437 (0.216–0.882) | 0.02 | 0 | 0.613 |
| NOS score | |||||||
| 9 | 3 | 247 | 1.857 (1.203–2.865) | 1.848 (1.195–2.858) | 0.005 | 0 | 0.574 |
| Less than 9 | 26 | 1415 | 1.488 (1.235–1.792) | 1.504 (1.187–1.905) | < 0.0001 | 31.4 | 0.065 |
| Tumor size (big vs small) | 23 | 1324 | 1.509 (1.245–1.829) | 1.557 (1.217–1.992) | < 0.0001 | 31.7 | 0.074 |
| SNHG expression | |||||||
| High SNHG expression | 21 | 1219 | 1.645 (1.344–2.013) | 1.664 (1.325–2.091) | < 0.0001 | 14.9 | 0.264 |
| Low SNHG expression | 2 | 105 | 0.584 (0.296–1.149) | 0.587 (0.293–1.176) | 0.119 | 2.5 | 0.311 |
| NOS score | |||||||
| 9 | 1 | 66 | 1.917 (0.820–4.478) | 1.917 (0.820–4.478) | 0.133 | - | - |
| less than 9 | 22 | 1258 | 1.489 (1.222–1.814) | 1.545 (1.194–2.001) | 0.001 | 34.1 | 0.061 |
| Histological grade | 9 | 567 | 1.248 (0.938–1.661) | 1.247 (0.936–1.660) | 0.128 | 0 | 0.97 |
| NOS score | |||||||
| 9 | 2 | 184 | 1.380 (0.831–2.291) | 1.378 (0.828–2.292) | 0.213 | 0 | 0.43 |
| Less than 9 | 7 | 383 | 1.191 (0.843–1.683) | 1.190 (0.842–1.683) | 0.321 | 0 | 0.962 |
| DM (present vs. absent) | 3 | 136 | 0.933 (0.463–1.882) | 0.933 (0.462–1.885) | 0.848 | 0 | 0.929 |
| Invasion depth (T3+T4/T1+T2) | 1 | 40 | 1.029 (0.297–3.566) | 1.029 (0.297–3.566) | 0.965 | - | - |
TNM Tumor Node Metastasis, LNM Lymph node metastasis, DM Distant metastasis, CI Confidence interval, No. Number, NA Not applicable