Table 5.
Regulation mechanism of SNHG involved in lung cancers
| Lnc RNA | Expression level | Role | micro-RNA | Downstream targets or pathways | Cell line | Function (high snhg expression) | Reference |
|---|---|---|---|---|---|---|---|
| SNHG1 | upregulated | oncogene | miR-101-3p | ROCK2 | A549, A549/DDP,NCI-H520/DDP | reduce cisplatin sensitivity | Wei L 2019 [54] |
| SNHG1 | upregulated | oncogene | miR-101-3p | Wnt/β-catenin signaling | A549, SPC-A1, H23 and NCI-H520 | promote proliferation and cell cycle, suppress apoptosis | Cui Y 2017 [28] |
| SNHG1 | upregulated | oncogene | miR-361-3p | FRAT1 | BEAS-2B, H23, H1299 | induce cell proliferation, migration,invasion, inhibit apoptosis | Li XM 2020 [42] |
| SNHG1 | upregulated | oncogene | - | ZEB1 | H-266 and SK-MES-1 | promotes cell metastasis and invasion | Zhang HY 2017 [56] |
| GAS5 | downregulated | tumor suppressor gene | miR-217 | LHPP | H1299, A549, A549/DDP and H1299/DDP | reduced NSCLC/DDP cell migration, invasion and EMT process, reduces cisplatin-resistance | Yang XH 2021 [55] |
| SNHG3 | downregulated | tumor suppressor gene | miR-890 | - | HBE, A549, H1299, H1975 | Inhibits the Proliferation, Migration and Invasion, and Promotes the Apoptosis | Kang BJ 2021 [40] |
| SNHG3 | upregulated | oncogene | miR-1343-3p | NFIX | BEAS-2B, H1299, H358, A549 and H1975 | promotes proliferation, migration and invasion and inhibits apoptosis | Zhao LJ 2021 [60] |
| SNHG3 | upregulated | oncogene | - | IL‐6/JAK2/STAT3 pathway | CMT‐167, LLC, CMT‐170, and CMT‐181 | promotes proliferation and migration | Shi JD 2019 [49] |
| SNHG3 | upregulated | oncogene | miR-216a | ZEB1 | A549, H322, H1299, GLC-82, and SPC-A1 | induce Proliferation, Migration and Invasion, and suppress Apoptosis | Zhao SS 2020 [21] |
| SNHG4 | upregulated | oncogene | miR-let-7e | KDM3A/p21 pathway | H1299, H1650, H1975, and SPCA1 | promotes proliferation, migration and invasion and inhibits apoptosis | Wang F 2020 [50] |
| SNHG5 | downregulated | tumor suppressor gene | miR-377 | miR377/CASP1 axis | PC9 and A549 | enhances gefitinib sensitivity | Wang ZX 2018 [63] |
| SNHG6 | upregulated | oncogene | miR-485-3p | VPS45 | BEAS-2B, H520, H596, H1650, H1703 | induce cell growth, migration and invasion | Gao N 2020 [32] |
| SNHG6 | upregulated | oncogene | miR-490-3p | RSF1, Bcl-2, bax, caspase-3 | A549, H460 and H1299 | Promotes Proliferation and Inhibits Apoptosis | Dong Z 2020 [30] |
| SNHG6 | upregulated | oncogene | - | ETS1, MMP2, MMP9 | A549, H226, H292, ANP973 and H1299 | promotes proliferation and migration | Geng H 2020 [33] |
| SNHG6 | upregulated | oncogene | miR-26a-5p | E2F7 | A549, H1299, H460,HCC827, NCl-H358 and NCl-H1650 | promotes cell proliferation, migration, invasion, and EMT and induces cell cycle progression | Liang R 2018 [44] |
| SNHG7 | upregulated | oncogene | miR-449a | miR-449a/TGIF2 axis | BEAS-2B, A549 and H1299 | contributes to cell proliferation, migration, invasion and EMT process | Pang LL 2019 [48] |
| SNHG7 | upregulated | oncogene | miR-181a-5p | AKT/mTOR Signaling Pathway | A549, NCI-H1299 | Accelerates Proliferation, Migration and Invasion | Li LP 2020 [41] |
| SNHG8 | upregulated | oncogene | miR-542-3p | CCND1/CDK6 | (A549, H23, SPC-A1, and NCI-H292 | contributes to cell proliferation | Chen CH 2018 [24] |
| SNHG9 | upregulated | oncogene | - | CAPRIN1 | BEAS-2B, SK-MES-1, H460, A549 and H1299 | promoted DDP resistance | Wang RX 2020 [51] |
| SNHG10 | downregulated | tumor suppressor gene | miR-21 | - | KLN 205, HCC827 | increasing SNHG10 expression suppress cell proliferation | Liang M 2020 [64] |
| SNHG10 | downregulated | tumor suppressor gene | miR-543 | SIRT1 | H1581 and H1703 | increasing SNHG10 expression suppress cell proliferation | Zhang Z 2020 [65] |
| SNHG11 | upregulated | oncogene | miR‐4436a | Wnt/β‐catenin signaling pathway | A549, H1299, H460 | facilitated lung cancer cell prol iferation, migration, invasion, and EMT process while suppressed cell apoptosis | Liu SX 2019 [46] |
| SNHG12 | upregulated | oncogene | - | HuR/PD-L1/USP8 axis | A549, SW1573, H1975, H1299 | induce immune escape | Huang YS 2022 [37] |
| SNHG12 | upregulated | oncogene | miR-218 | Slug/ZEB2 signaling pathway | A549, H1299 | Accelerates Migration and EMT process | Wang Y 2019 [20] |
| SNHG13 | upregulated | oncogene | miR-758-3p | - | SPC-A1 and NCI-H1299 | promotes tumor NSCLC cell migration and invasion | Wang S 2018 [52] |
| SNHG13 | upregulated | oncogene | - | p21 | A549, H1299 and H358 | contributes to cell proliferation, migration, invasion and EMT process | Guo LF 2019 [34] |
| SNHG13 | upregulated | oncogene | miR-1225-3p | ErbB2 | A549, SPCA1, H1299 and H1975 | Enhanced Migration and Invasion | Huang YF 2021 [38] |
| SNHG13 | upregulated | oncogene | - | HMGA2 | SPCA1 and A549 | promotes invasion | Zhang NN 2021 [57] |
| SNHG14 | upregulated | oncogene | miR-382-5p | SPIN1 | H1299, A549 | induce Proliferation, Migration and Invasion, and suppress Apoptosis | Chen XL 2020 [25] |
| SNHG14 | upregulated | oncogene | miR-340 | - | 16HBE, A549, NCI-H1975, NCI-H1299, SK-MES-1 | induce Proliferation and suppress Apoptosis | Zhang ZH 2018 [58] |
| SNHG15 | upregulated | oncogene | miR-211-3p | ZNF217 | HBEC3, H358, H1299, H23 and A549 | Promoted Proliferation and Migration | Ma XR 2019 [47] |
| SNHG15 | upregulated | oncogene | miR-211-3p | - | H1799 and A549 | promotes proliferation and migration | Cui HX 2018 [27] |
| SNHG15 | upregulated | oncogene | miR-486 | CDK14 | A549, H460, SK-MES-1, and Calu-3 | induce Proliferation, Migration and Invasion, and suppress Apoptosis | Jin B 2018 [39] |
| SNHG16 | upregulated | oncogene | - | ALDH2, Bax, Bcl-2 | A549 and SK-LU-1 | cell proliferation | Li Y 2022 [43] |
| SNHG16 | upregulated | oncogene | miR-146a | MUC5AC | A549, NCI-H292, NCI-H460, and NCI-H1703 | promotes NSCLC cell proliferation, migration and invasion | Han W 2018 [36] |
| SNHG17 | upregulated | oncogene | miR-193a-5p | NETO2 | BEAS-2B, A549, H1299, H1650, H1975 and CALU-3 | facilitate migration, invasion, proliferation and EMT | Zhang ZW 2021 [59] |
| SNHG18 | upregulated | oncogene | miR-211-5p | miR-211-5p/BRD4 axis | A549, H1299, H23, H460, and H1792 | promotes NSCLC cell proliferation, migration and invasion | Fan HJ 2021 [31] |
| SNHG20 | upregulated | oncogene | miR-154 | ZEB2 and RUNX2 | A549, H322, H1299, GLC-82, and SPC-A1 | promotes proliferation, migration and invasion, and suppresses apoptosis | Jin LL 2019 [45] |
| SNHG20 | upregulated | oncogene | - | P21 | PC9, SPC-A1, NCIH1975, H1299 and A549 | promotes cell proliferation and migration | Chen ZY 2017 [26] |
| SNHG20 | upregulated | oncogene | miR-342 | DDX49 | BEAS-2B, A549 and H1299 | promoted proliferation, invasion and inhibited cell apoptosis | Wang XL 2020 [53] |
ROCK2 Rho-associated coiled-coil containing protein kinase 2, FRAT1 FRAT Regulator Of WNT Signaling Pathway 1, ZEB1 Zinc finger E-box-binding homeobox protein 1, LHPP Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase, NFIX Nuclear Factor I X, JAK2 Janus kinase 2, KDM3A Lysine Demethylase 3A, CASP1 Caspase 1, VPS45 Vacuolar Protein Sorting 45 Homolog, RSF1 Remodeling And Spacing Factor 1, MMP2 Matrix metalloproteinase 2, MMP9 Matrix metalloproteinase 9, E2F7 E2F Transcription Factor 7, TGIF2 TGFB Induced Factor Homeobox 2, CCND1 Cyclin D1, CDK6 Cyclin-dependent kinase 6, SIRT1 Sirtuin 1, ErbB2 Human epidermal growth factor receptor 2, HMGA2 High Mobility Group AT-Hook 2, SPIN1 Spindlin 1, ZNF217 Zinc Finger Protein 217, CDK14 Cyclin-dependent kinase 14, ALDH2 Acetaldehyde dehydrogenase 2, MUC5AC Mucin 5AC, NETO2 Neuropilin And Tolloid Like 2, ZEB2 Zinc finger E-box binding homeobox (Zeb) 2, RUNX2 Runt-related transcription factor 2, DDX49 DEAD-Box Helicase 49