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. 2023 Dec 15;32:09636897231219830. doi: 10.1177/09636897231219830

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — 3D-RM-EVs equipped with drugs inhibit mouse osteosarcoma progression in vivo. (A) osteosarcoma mice (K7M2 bearing mice), histological analysis showed that the K7M2 osteosarcoma was a cancerous tissue attached to the periosteum of the bone, control: means normal tissue. (B) Tumor morphology observation showed that the 3D-RM-EVs + IFO + ET group had the most significant tumor inhibition effect, while the control group had the largest tumor. (C) Tumor weight analysis indicated that the tumor weight in the 3D-RM-EVs + IFO + ET group (2.12 ± 0.265 g) was significantly lighter than that in the control group (3.86 ± 0.232 g), 3D-RM-EVs group (3.70 ± 0.286 g), and IFO + ET group (2.92 ± 0.317 g). (D) Tumor growth curve analysis indicated that co-incubation of 3D-RM-EVs with osteosarcoma therapeutic drugs (Ifosfamide + Etoposide) had the best effect. (E) Weight changes of mice during treatment, there was no difference in weight between the 3D-RM-EVs group and the control group. The IFO + ET group had the most significant weight loss, while the 3D-RM-EVs + IFO + ET group could slow down weight loss compared with IFO + ET group. The error bars: standard errors of the mean from three independent experiments. RM: reserve mesenchymal; EV: extracellular vesicle; IFO-ET: Ifosfamide + Etoposide. *P < 0.05; **P < 0.01.