Table 2.
Summary of Qualitative and Quantitative Assessment of MNV Morphology Secondary to Myopic Macular Degeneration (MMD) and Age-Related Macular Degeneration (AMD) Using SS-OCTA
| MMD n=11 Eyes | AMD n=33 Eyes | p-value | ||
|---|---|---|---|---|
| MNV type | 1 | 6/11 (55) | 31/33 (94) | 0.006 |
| 2 | 4/11 (36) | 1/33 (3) | ||
| 3 | 1/11 (9) | 1/33 (3) | ||
| Location | Subfoveal | 8/11 (73) | 24/33 (73) | 1.000 |
| Foveal sparing | 3/11 (27) | 9/33 (27) | ||
| MNV activitya | Active | 6/11 (55) | 26/33 (79) | 0.018 |
| Scar | 4/11 (36) | -- | -- | |
| Atrophic | 1/11 (9) | -- | -- | |
| Silent | -- | 6/33 (18) | -- | |
| Quiescent | -- | 1/33 (3) | -- | |
| Shape | Round | 6/11 (55) | 14/33 (42) | 0.484 |
| Irregular | 5/11 (45) | 19/33 (58) | ||
| Pattern | Medusa | 3/11 (27) | 17/33 (52) | 0.033 |
| Sea-fan | 2/11 (18) | 11/33 (33) | ||
| Tree-in-bud | 6/11 (55) | 5/33 (15) | ||
| Well-defined margins | 7/11 (64) | 26/33 (79) | 0.315 | |
| Presence of a core vessel | 1/11 (9) | 8/33 (24) | 0.281 | |
| Presence of capillary fringe | 4/11 (36) | 18/33 (55) | 0.296 | |
| Presence of perilesional dark halo | 3/11 (27) | 13/33 (39) | 0.469 | |
| Presence of peripheral loops/arcades | 8/11 (73) | 28/33 (85) | 0.367 | |
| Greatest linear dimension | Length (mm) | 1.41±0.90 | 2.44±1.38 | 0.009 |
| Angle (degrees) | −15.0±83.1 | −34.2±61.3 | 0.491 | |
| Greatest vascular caliber (mm) | 0.038±0.012 | 0.067±0.041 | <0.001 | |
| MNV area (mm2) | 1.38±1.53 | 4.73±4.86 | 0.001 | |
| Vessel density (%) | 51.7±14.9 | 42.0±11.7 | 0.071 | |
| Branching Index | 69.5±48.5 | 47.3±28.5 | 0.175 | |
| Total vessels length | 12.5±12.6 | 36.0±33.8 | 0.002 | |
| Mean vessels length | 6.39±10.16 | 4.40±3.67 | 0.537 | |
| Mean lacunarity | 0.197±0.111 | 0.205±0.121 | 0.844 | |
Notes: aMNV activity was classified as active, silent (treatment-free interval ≥ 3 months) or quiescent (or treatment-naïve) for eyes with AMD-MNV and in the active, scar or atrophic stages for MMD-MNV based on established criteria.10–12 The data is presented as mean ± standard deviation where applicable. The data in parentheses is presented as a percentage (%), and significant p-values (<0.05) are highlighted in bold.