Table 1.
Baseline Demographics and Disease Characteristics
| Characteristic | HLA-Cw6 Positive (N=128) | HLA-Cw6 Negative (N=166) | Overall Patient Cohort† (N=297) |
|---|---|---|---|
| Age (years) | 42.8±13.7 | 48.5±13.0 | P < 0.001 |
| 45.9±13.5 | |||
| Age categories (years), n (%) | P = 0.521 | ||
| <65 | 117 (91.4) | 148 (89.2) | 268 (90.2) |
| ≥65 | 11 (8.6) | 18 (10.8) | 29 (9.8) |
| Sex, n (%) | P = 0.358 | ||
| Male | 87 (68.0) | 121 (72.9) | 210 (70.7) |
| Female | 41 (32.0) | 45 (27.1) | 87 (29.3) |
| Race, n (%) | P = 1.000 | ||
| Caucasian | 128 (100.0) | 162 (97.6) | 293 (98.7) |
| Weight (kg) | 77.5±15.1 | 83.9±17.8 | P < 0.001 |
| 81.2±17.0 | |||
| Height (cm) | 171.9±9.1 | 171.6±9.4 | P = 0.791 |
| 171.6±9.2 | |||
| BMI categories (kg/m2), n (%) | P = 0.013 | ||
| <25 | 54 (42.2) | 47 (28.3) | 101 (34.0) |
| ≥25 | 74 (57.8) | 119 (71.7) | 196 (66.0) |
| Waist circumference (cm), n | 116 | 158 | 277 (P < 0.001) |
| 92.7±13.9 | 99.7±16.0 | 96.9±15.6 | |
| Smoking status, n (%) | P = 0.060 | ||
| Never | 42 (32.8) | 74 (44.6) | 118 (39.7) |
| Current | 68 (53.1) | 65 (39.2) | 133 (44.8) |
| Former | 18 (14.1) | 27 (16.3) | 46 (15.5) |
| Absolute PASI | 21.0±9.1 | 22.5±10.9 | 21.9±10.2 |
| Type of psoriasis history at diagnosis, n (%) | |||
| Nail psoriasis | 46 (35.9) | 65 (39.2) | 113 (38.1) |
| Scalp psoriasis | 95 (74.2) | 133 (80.1) | 231 (77.8) |
| Age at diagnosis of psoriasis (years) | 23.6±13.1 | 31.1±14.5 | 27.8±14.4 |
| Time since first diagnosis of psoriasis (years), n | 128 | 166 | 297 |
| 19.7±12.4 | 17.9±11.5 | 18.7±11.9 | |
| Number of patients with psoriatic arthritis, n (%) | 21 (16.4) | 40 (24.1) | 62 (20.9) |
| Type of psoriatic arthritis, n (%) | |||
| Polyarticular | 19 (14.8) | 33 (19.9) | 53 (17.9) |
| Monoarticular | 1 (0.8) | 4 (2.4) | 5 (1.7) |
| Axial | 4 (3.1) | 7 (4.2) | 11 (3.7) |
| Enthesitis | 4 (3.1) | 6 (3.6) | 10 (3.4) |
| Dactylitis | 7 (5.5) | 8 (4.8) | 15 (5.1) |
| Time since first diagnosis of psoriatic arthritis (years), n | 20 | 39 | 60 |
| 8.4±8.3 | 10.8±9.4 | 9.8±9.1 |
Notes: P-values for categorical variables were calculated using the chi-square test or Fisher exact test and those for continuous variables were calculated using the t-test. The data are mean±SD unless specified otherwise. †Three patients with missing HLA-Cw6 assessments are included in the “overall patient cohort” column.
Abbreviations: BMI, body mass index; HLA, human leucocyte antigen; N, number of patients in the population; n, number of patients; PASI, Psoriasis Area and Severity Index; SD, standard deviation.