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Spongiform degeneration (arrow) and the accumulation of prion protein (arrowhead) are consistent pathological features of prion disease, along with astrocytosis and neuronal degeneration. Shown is a section of neocortex from a patient who died of idiopathic Creutzfeldt-Jakob disease, labeled using the anti-PrP antibody 3F4 (Nissl counterstain). Bar = 50μm.
