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Course of the total scores of the Positive And Negative Syndrome Scale (PANSS) in the groups with comorbid substance use disorder (SUD) and the non-comorbid group (non-SUD). Both groups obtained >50% reduction from baseline to endpoint, compatible with clinical response, but similarly to what occurred with the BPRS-24, the non-SUD group scored constantly lower throughout the study, indicating that the non-comorbid group was clinically better than the comorbid SUD group.
