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. 2023 Dec 4;14:1276951. doi: 10.3389/fmicb.2023.1276951

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Copyright © 2023 Yang, Wang, Jiang, Zhang, Du, Li and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The microbial proteins identified from gallstone and polyp bile samples. (A) Abundance rank of identified proteins. The intensity of each protein was determined by summing up the LFQ values across all samples. Microbial proteins were highlighted. (B) The abundance of differential microbial proteins between CHL (n = 31) and polyp (n = 9) patients. (C) The differential microbial proteins between acute CHL (n = 14) and polyp (n = 9) patients. (D) The differential microbial proteins between chronic CHL (n = 17) and polyp (n = 9) patients. (E) Three microbial proteins upregulated in CHL compared to polyp. p values were calculated using Welch’s t test. (F) The differential microbial proteins between acute CHL (n = 14) and chronic CHL (n = 17) patients.