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. Author manuscript; available in PMC: 2023 Dec 18.
Published in final edited form as: Cell Rep. 2023 Nov 1;42(11):113351. doi: 10.1016/j.celrep.2023.113351

Figure 5. Predicted regulatory variants are largely tissue specific and differentially affect SBP and DBP.

Figure 5.

Three different groups of variants are considered: (A) all variants in regions around expressed genes, (B) all variants in CREs, and (C) impactful regulatory variants predicted by deltaSVM. In each group, variants were further divided into six different classes based on overlaps across the four tissues (see Figure 3). Variants in the “common category” affect all four tissues, while variants in the “mixed category” affect more than one, but not all, tissues. For each variant group, bar plots show the proportion of SNPs (top), the proportion of SNP heritability explained (middle), and the enrichment score (bottom) across six variant classes. Error bars are standard errors estimated using the LDSC block jackknife method (n = 200 blocks). Asterisks indicate the statistical significance based on Z scores from S-LDSC coefficients (*p < 0.01, **p < 0.001, ***p < 0.0001).