Table 2.

Summary of Three-Dimensional Construct Protein Expression in HCF and HKCs Stimulated with FSH and LH

Name	FSH			LH			FSH versus LH
	HCF	HKC	HCF versus HKC	HCF	HKC	HCF versus HKC	HCF	HKC
GnRHR
AR			Up ↑					Down ↓
PR				Up ↑		Down ↓
ERβ				Up ↑	Up ↑			Up ↑
ERα						Down ↓		Down ↓
α-SMA		Down ↓			Down ↓	Down ↓
EDA-Fn					Down ↓	Down ↓
Keratocan			Down ↓	Up ↑		Down ↓	Up ↑
Lumican	Down ↓	Down ↓		Down ↓	Down ↓
CYP3A4
PKA					Down ↓
CRH
GPER					Up ↑	Up ↑		Up ↑
cAMP
CREB						Up ↑
ERK 1/2
pan-AKT	Up ↑						Down ↓
JNK			Down ↓

AR, androgen receptor; CREB, cAMP response element–binding protein; CRH, corticotropin-releasing hormone; CYP, cytochrome P450; EDA-Fn, fibronectin-containing extra domain A; ER, estrogen receptor; GnRHR, gonadotropin-releasing hormone receptor; GPER, G protein–coupled estrogen receptor; JNK, c-Jun N-terminal kinase; pan-AKT, protein kinase B with potential antineoplastic activity; PKA, protein kinase A; PR, progesterone receptor; SMA, smooth muscle actin.