Skip to main content
. 2023 Nov 27;14(12):1774–1784. doi: 10.1021/acsmedchemlett.3c00354

Table 1. Inhibition Profile of CZC-54252 (1) across the Panel of 11 P. falciparum Kinases.

kinase % activity remaining at 1 μMa IC50 (μM)b
PfARK1 53 3.4
PfARK3 50 1.8
PfCDPK2 78  
PfCDPK5 97  
PfGSK3 94  
PfNEK1 85  
PfNEK3 34 1.0
PfPK5 90  
PfPK6 90  
PfPK9 43 1.2
PfPKB 11 0.070
a

Mean values from duplicate experiments using the KinaseSeeker assay.

b

Mean values from two experiments using the KinaseSeeker assay performed in duplicate.