Table 5. Antiplasmodial Activity and Cytotoxicity.

	Pf3D7 blood stage
compound	% viability at 1 μMa	EC50 (μM)b	HepG2 CC50 (μM)c	CC50/EC50
1	21	0.34
2	85
4	15	0.69	9.8	14
5	14	0.54	>15d	>28
6	110
7	83
8	39	1.2	23	19
9	14	0.38	>15d	>39
14	21	0.43	>50e	>116
23	95
24	82
25	78
27	65
31	28	0.43	1.5	3.5
33	82
34	85
35	69
36	90
37	15	0.16	1.6	10
38	10	0.35	2.1	6.1
39	7	0.43	2.8	6.4
40	57

^aMean values of triplicate experiments using the SYBR Green I-based assay.

^bMean values from two experiments performed in duplicate using the SYBR Green I-based assay.

^cMean values from two experiments performed in triplicate using the CellTiter-Fluor assay.

^dNo significant cytotoxicity observed up to 15 μM, the observed solubility limit.

^eDecreases cell viability around 1 μM to ∼60%, but never decreases cell viability below 50%.