Table 6. Solubility, Permeability, Plasma Protein Binding, and Plasma Stability.
| compd | kinetic solubility in PBS pH 7.4 (μM)a | PAMPA Pe (×10–6 cm/s)b | human PPB (% bound)a | human plasma stability (% remaining at 6 h)a |
|---|---|---|---|---|
| 1 | 71.1 | 21.4 | 99.0 | 97 |
| 4 | 46.8 | 18.2 | 99.3 | 101 |
| 5 | 21.0 | 15.5 | 99.5 | 99 |
| 8 | 36.0 | 14.8 | 97.6 | 101 |
| 9 | 1.1 | 17.8 | 97.6 | 103 |
| 14 | 0.9 | 15.1 | 94.6 | 92 |
| 31 | 8.5 | 19.1 | 95.9 | 105 |
| 37 | 116.0 | 20.9 | 98.6 | 103 |
| 38 | 12.8 | 20.9 | 99.1 | 101 |
| 39 | 0.4 | 12.0 | 99.4 | 98 |
a
Mean values of duplicate experiments.
b
Mean values of triplicate experiments.