Table 2. PK Parameters for 13 and 17 in Balb/c Mice.
property | 13 | 17 |
---|---|---|
clearance (mL/min/kg) | 17.4 | 2.01 |
half-life (h) | 0.4 | 1.0 |
Vss (L/kg) | 0.20 | 0.14 |
oral dose (mg/kg) | 10 | 5 |
oral AUC (ng·h/mL) | 5,780 | 22,900 |
oral Cmax (ng/mL) | 2,500 (8.93 μM) | 19,600 (73.96 μM) |
bioavailability (%F) | 60 | 56 |