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. 2023 Nov 21;14(12):1700–1706. doi: 10.1021/acsmedchemlett.3c00336

Table 2. PK Parameters for 13 and 17 in Balb/c Mice.

property 13 17
clearance (mL/min/kg) 17.4 2.01
half-life (h) 0.4 1.0
Vss (L/kg) 0.20 0.14
oral dose (mg/kg) 10 5
oral AUC (ng·h/mL) 5,780 22,900
oral Cmax (ng/mL) 2,500 (8.93 μM) 19,600 (73.96 μM)
bioavailability (%F) 60 56