Fig. 3.

Basic condensates promoting features. A-C Interactions between macromolecules that facilitate phase separation. D The SH2 domain of NCK binds to Nephrin, and NCK possesses three SH3 domains that can bind the proline-rich motifs (PRMs) of N-WASP, showing a typical repetitive molecular domain (RMD) that contributes to LLPS. E Oligomerization of SPOP and its interactions with substrates can induce phase separation. F Dimerization of HP1a promotes LLPS. G–I Several classic IDRs, which consist of LCDs. J–N Fundamental interacting force between IDRs. O Formation of BMCs, from dissociation to assembly. P–S Four types of sequence variations that drive phase separation