Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 18;42:344. doi: 10.1186/s13046-023-02921-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — GABA inhibits ubiquitination of cMYC and promotes proliferation and migration of CRC. A The proliferation of colon cancer cells was assessed via CCK-8 for 3 days. B The proliferation of colon cancer cells was assessed via colony formation assay for 10 days. C, D The wound healing assays showed that GABA significantly augmented the migrative ability of colon cancer cells. E The transwell assays indicated that GABA increased the migrative ability of colon cancer cells. F, H Treatment with GABA increased the volume and weight of subcutaneous tumors. G The solid tumors were peeled off and the weight was measured. H The volume of transplanted tumors was measured by the Vernier caliper per week. I, J The number of tumors in the lung was counted upon treated with GABA or PBS. K HE staining showed the tumors in the lung of mice. All data were revealed as mean ± standard deviation (SD) for no less than three independent experiments. Significant P values showed as ^***P < 0.001.^**P < 0.01