Table 2.
Detailed information on SNPs used in MR analyses
| Bacterial taxa | SNP | Effect allele | Other allele | F | palindromic | exposure | outcome | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | SE | pval | Beta | SE | pval | ||||||
| Genus Eubacteriumbrachygroup(id.11296) | rs12151423 | A | G | 19.869 | FALSE | 0.101 | 0.023 | 8.29E-06 | 0.163 | 0.149 | 0.272 |
| rs13139592 | T | C | 19.910 | FALSE | -0.146 | 0.033 | 8.12E-06 | 0.099 | 0.221 | 0.653 | |
| rs1384962 | A | G | 20.613 | FALSE | 0.121 | 0.027 | 5.62E-06 | 0.236 | 0.161 | 0.142 | |
| rs2913110 | C | T | 21.004 | FALSE | 0.105 | 0.023 | 4.58E-06 | 0.070 | 0.156 | 0.654 | |
| rs4862235 | G | A | 21.553 | FALSE | 0.105 | 0.023 | 3.44E-06 | 0.194 | 0.150 | 0.195 | |
| rs55932844 | A | G | 22.357 | FALSE | -0.171 | 0.036 | 2.26E-06 | -0.247 | 0.266 | 0.352 | |
| rs62348779 | T | C | 21.666 | FALSE | -0.201 | 0.043 | 3.25E-06 | -0.581 | 0.281 | 0.039 | |
| rs6591893 | G | A | 20.281 | FALSE | 0.108 | 0.024 | 6.69E-06 | -0.007 | 0.157 | 0.967 | |
| rs720439 | A | G | 19.845 | FALSE | -0.112 | 0.025 | 8.40E-06 | -0.212 | 0.173 | 0.221 | |
| rs73199919 | T | C | 19.848 | FALSE | -0.237 | 0.053 | 8.38E-06 | 0.357 | 0.349 | 0.307 | |
| rs9613196 | T | A | 20.398 | TRUE | -0.239 | 0.053 | 6.29E-06 | -0.474 | 0.379 | 0.212 | |
| Genus Faecalibacterium(id.2057) | rs10927394 | G | T | 20.549 | FALSE | -0.232 | 0.051 | 5.81E-06 | -0.451 | 0.538 | 0.402 |
| rs114946999 | C | T | 20.649 | FALSE | -0.086 | 0.019 | 5.52E-06 | -0.152 | 0.224 | 0.499 | |
| rs11776390 | T | C | 20.793 | FALSE | -0.078 | 0.017 | 5.12E-06 | 0.191 | 0.302 | 0.527 | |
| rs12320842 | C | G | 33.453 | TRUE | 0.095 | 0.016 | 7.30E-09 | -0.018 | 0.217 | 0.933 | |
| rs1271565 | C | T | 23.195 | FALSE | -0.058 | 0.012 | 1.46E-06 | 0.217 | 0.170 | 0.200 | |
| rs12753492 | A | C | 18.295 | FALSE | 0.064 | 0.015 | 1.89E-05 | -0.271 | 0.235 | 0.248 | |
| rs2835874 | T | C | 19.440 | FALSE | -0.087 | 0.020 | 1.04E-05 | 0.018 | 0.390 | 0.963 | |
| rs28376661 | C | G | 21.305 | TRUE | 0.050 | 0.011 | 3.92E-06 | -0.100 | 0.162 | 0.538 | |
| rs61875484 | C | G | 19.828 | TRUE | 0.082 | 0.018 | 8.47E-06 | -0.434 | 0.255 | 0.089 | |
| rs6910935 | A | G | 23.699 | FALSE | 0.135 | 0.028 | 1.13E-06 | -0.492 | 0.310 | 0.112 | |
| rs75499067 | C | T | 23.900 | FALSE | 0.228 | 0.047 | 1.01E-06 | -0.340 | 0.284 | 0.231 | |
| rs79656633 | T | C | 20.326 | FALSE | 0.146 | 0.032 | 6.53E-06 | -0.582 | 0.249 | 0.019 | |
| rs9536330 | T | C | 20.026 | FALSE | -0.048 | 0.011 | 7.64E-06 | 0.092 | 0.149 | 0.537 | |
| Genus Prevotella7(id.11182) | rs11035469 | A | G | 21.365 | FALSE | -0.144 | 0.031 | 3.80E-06 | 0.231 | 0.176 | 0.188 |
| rs118038478 | A | G | 19.239 | FALSE | 0.206 | 0.047 | 1.15E-05 | -0.403 | 0.291 | 0.166 | |
| rs12124567 | A | G | 19.448 | FALSE | -0.121 | 0.028 | 1.03E-05 | -0.022 | 0.187 | 0.905 | |
| rs12195431 | T | C | 19.741 | FALSE | 0.197 | 0.044 | 8.87E-06 | -0.022 | 0.255 | 0.931 | |
| rs16937247 | G | C | 17.273 | TRUE | 0.146 | 0.035 | 3.24E-05 | -0.008 | 0.188 | 0.966 | |
| rs2240542 | C | T | 21.312 | FALSE | 0.121 | 0.026 | 3.90E-06 | -0.185 | 0.169 | 0.271 | |
| rs2918132 | C | T | 20.228 | FALSE | -0.115 | 0.025 | 6.88E-06 | 0.340 | 0.155 | 0.028 | |
| rs385483 | A | G | 22.038 | FALSE | 0.137 | 0.029 | 2.67E-06 | -0.272 | 0.184 | 0.139 | |
| rs57404562 | C | A | 24.202 | FALSE | 0.155 | 0.032 | 8.67E-07 | -0.049 | 0.220 | 0.826 | |
| rs9426434 | T | C | 19.713 | FALSE | -0.124 | 0.028 | 9.00E-06 | 0.019 | 0.157 | 0.903 | |
| rs9608249 | A | G | 22.130 | FALSE | -0.158 | 0.034 | 2.55E-06 | 0.162 | 0.233 | 0.486 | |
| rs9959718 | G | A | 23.333 | FALSE | 0.133 | 0.028 | 1.36E-06 | -0.179 | 0.184 | 0.330 | |
| Family Ruminococcaceae(id.2050) | rs10093275 | C | T | 20.960 | FALSE | 0.053 | 0.012 | 4.69E-06 | -0.038 | 0.158 | 0.809 |
| rs10166469 | T | C | 19.686 | FALSE | -0.053 | 0.012 | 9.12E-06 | 0.086 | 0.170 | 0.612 | |
| rs117677831 | G | A | 27.172 | FALSE | 0.098 | 0.019 | 1.86E-07 | -0.049 | 0.268 | 0.856 | |
| rs1612733 | T | C | 20.862 | FALSE | 0.109 | 0.024 | 4.94E-06 | -0.722 | 0.329 | 0.028 | |
| rs17376049 | T | C | 24.306 | FALSE | 0.085 | 0.017 | 8.22E-07 | -0.525 | 0.236 | 0.026 | |
| rs2113833 | T | C | 22.701 | FALSE | 0.169 | 0.036 | 1.89E-06 | -0.345 | 0.415 | 0.405 | |
| rs2426816 | T | A | 20.514 | TRUE | -0.048 | 0.011 | 5.92E-06 | 0.104 | 0.149 | 0.483 | |
| rs3009418 | C | A | 19.489 | FALSE | 0.093 | 0.021 | 1.01E-05 | -0.080 | 0.354 | 0.822 | |
| rs499272 | G | C | 19.382 | TRUE | 0.071 | 0.016 | 1.07E-05 | 0.198 | 0.224 | 0.377 | |
| rs56199908 | T | C | 23.584 | FALSE | -0.199 | 0.041 | 1.20E-06 | 0.730 | 0.331 | 0.027 | |
| rs76724913 | T | G | 19.682 | FALSE | 0.090 | 0.020 | 9.15E-06 | -0.517 | 0.254 | 0.042 | |
| Genus Anaerostipes(id.1991) | rs10502061 | A | G | 18.944 | FALSE | 0.084 | 0.019 | 1.35E-05 | -0.059 | 0.233 | 0.800 |
| rs13376554 | A | T | 18.522 | TRUE | 0.197 | 0.046 | 1.68E-05 | -0.360 | 0.472 | 0.445 | |
| rs2014785 | T | C | 21.125 | FALSE | 0.052 | 0.011 | 4.30E-06 | -0.221 | 0.152 | 0.145 | |
| rs2396460 | T | C | 21.897 | FALSE | -0.051 | 0.011 | 2.88E-06 | 0.131 | 0.150 | 0.382 | |
| rs2804244 | A | G | 22.882 | FALSE | -0.053 | 0.011 | 1.72E-06 | 0.171 | 0.153 | 0.262 | |
| rs3900776 | G | A | 21.675 | FALSE | -0.110 | 0.024 | 3.23E-06 | -0.280 | 0.443 | 0.528 | |
| rs60983350 | G | A | 21.449 | FALSE | -0.054 | 0.012 | 3.63E-06 | 0.048 | 0.161 | 0.766 | |
| rs62157625 | T | C | 22.787 | FALSE | 0.089 | 0.019 | 1.81E-06 | -0.079 | 0.227 | 0.727 | |
| rs62215703 | G | A | 22.260 | FALSE | 0.064 | 0.014 | 2.38E-06 | -0.069 | 0.181 | 0.704 | |
| rs6474958 | A | G | 19.935 | FALSE | -0.050 | 0.011 | 8.01E-06 | 0.167 | 0.160 | 0.295 | |
| rs6726833 | C | A | 21.463 | FALSE | -0.088 | 0.019 | 3.61E-06 | 0.711 | 0.276 | 0.010 | |
| rs6854026 | T | C | 21.732 | FALSE | -0.051 | 0.011 | 3.14E-06 | 0.081 | 0.150 | 0.588 | |
| rs7193624 | C | T | 24.803 | FALSE | 0.075 | 0.015 | 6.35E-07 | 0.126 | 0.269 | 0.641 | |
| rs7823228 | G | C | 20.669 | TRUE | -0.062 | 0.014 | 5.46E-06 | 0.242 | 0.199 | 0.224 | |
| rs78735375 | A | C | 20.262 | FALSE | -0.137 | 0.031 | 6.75E-06 | -0.049 | 0.380 | 0.898 | |
SNP Single nucleotide polymorphism, SE Standard error