Table 3.

The results of reverse MR analysis

Outcome Name (id)	No.of SNP	pleiotropy test (p. value)	Cochrane's Q heterogeneity test(Q_pval)	MR method	p.val	OR	or_lci95	or_uci95
Genus Prevotella7(id.11182)	9	0.621	0.861	ivw-fe	0.004	0.972	0.953	0.991
				MR Egger	0.232	0.955	0.890	1.023
				Simple mode	0.139	0.966	0.928	1.007
				Weighted mode	0.101	0.964	0.928	1.002
				Weighted median	0.015	0.969	0.945	0.994
Genus Anaerofilum(id.2053)	9	0.842	0.773	ivw-fe	0.017	1.020	1.004	1.037
				MR Egger	0.410	1.026	0.968	1.088
				Simple mode	0.623	1.009	0.974	1.045
				Weighted mode	0.619	1.009	0.976	1.042
				Weighted median	0.376	1.010	0.988	1.031
Genus Subdoligranulum(id.2070)	9	0.603	0.393	ivw-fe	0.009	1.012	1.003	1.021
				MR Egger	0.264	1.021	0.988	1.055
				Simple mode	0.523	1.007	0.986	1.028
				Weighted mode	0.562	1.006	0.987	1.026
				Weighted median	0.262	1.007	0.994	1.021
Family Veillonellaceae(id.2172)	9	0.380	0.752	ivw-fe	0.010	0.988	0.979	0.997
				MR Egger	0.876	1.003	0.971	1.035
				Simple mode	0.455	0.992	0.971	1.013
				Weighted mode	0.419	0.993	0.976	1.010
				Weighted median	0.198	0.992	0.979	1.004

No.of SNP, number of SNPs being used as IVs.; ivw-fe, fixed-effects inverse variance weighting; OR, Odds Ratio; or_lci95-or_uci95, 95% confidence interval; Significant P. value was marked in red