Table 4.

The detail information of SNPs in reverse MR analysis

Bacterial taxa (outcome)	SNP	Effect allele	Other allele	BETA		SE		P.val		palindromic	F
				exposure	outcome	exposure	outcome	exposure	outcome
genus.Anaerofilum(id.2053)	rs10513202	G	A	1.427	0.043	0.321	0.033	8.58E-06	0.188	FALSE	20
	rs11090513	T	G	0.798	0.007	0.175	0.023	5.00E-06	0.763	FALSE	21
	rs11230859	A	G	-0.725	-0.008	0.158	0.021	4.18E-06	0.713	FALSE	21
	rs12669698	C	T	1.127	0.030	0.255	0.032	9.73E-06	0.342	FALSE	20
	rs17145573	A	G	1.708	0.012	0.365	0.033	2.87E-06	0.721	FALSE	22
	rs389558	T	C	-0.783	-0.005	0.160	0.020	9.74E-07	0.793	FALSE	24
	rs491806	C	A	-0.948	-0.056	0.211	0.025	6.92E-06	0.023	FALSE	20
	rs529324	A	G	-0.826	-0.033	0.179	0.022	4.16E-06	0.130	FALSE	21
	rs7778345	G	A	0.730	-0.003	0.163	0.020	7.05E-06	0.880	FALSE	20
genus.Prevotella7(id.11182)	rs10513202	G	A	1.427	-0.019	0.321	0.038	8.58E-06	0.621	FALSE	20
	rs11090513	T	G	0.798	-0.007	0.175	0.028	5.00E-06	0.793	FALSE	21
	rs11230859	A	G	-0.725	0.022	0.158	0.025	4.18E-06	0.377	FALSE	21
	rs12669698	C	T	1.127	-0.039	0.255	0.038	9.73E-06	0.297	FALSE	20
	rs17145573	A	G	1.708	-0.072	0.365	0.039	2.87E-06	0.066	FALSE	22
	rs389558	T	C	-0.783	0.020	0.160	0.025	9.74E-07	0.430	FALSE	24
	rs491806	C	A	-0.948	0.040	0.211	0.029	6.92E-06	0.171	FALSE	20
	rs529324	A	G	-0.826	0.051	0.179	0.026	4.16E-06	0.048	FALSE	21
	rs7778345	G	A	0.730	0.010	0.163	0.024	7.05E-06	0.691	FALSE	20
genus.Subdoligranulum(id.2070)	rs10513202	G	A	1.427	0.004	0.321	0.017	8.58E-06	0.809	FALSE	20
	rs11090513	T	G	0.798	0.008	0.175	0.013	5.00E-06	0.502	FALSE	21
	rs11230859	A	G	-0.725	-0.008	0.158	0.011	4.18E-06	0.498	FALSE	21
	rs12669698	C	T	1.127	0.006	0.255	0.017	9.73E-06	0.716	FALSE	20
	rs17145573	A	G	1.708	0.048	0.365	0.017	2.87E-06	0.005	FALSE	22
	rs389558	T	C	-0.783	0.002	0.160	0.011	9.74E-07	0.876	FALSE	24
	rs491806	C	A	-0.948	0.004	0.211	0.013	6.92E-06	0.741	FALSE	20
	rs529324	A	G	-0.826	-0.007	0.179	0.012	4.16E-06	0.549	FALSE	21
	rs7778345	G	A	0.730	0.026	0.163	0.011	7.05E-06	0.018	FALSE	20
family.Veillonellaceae(id.2172)	rs10513202	G	A	1.427	0.003	0.321	0.018	8.58E-06	0.871	FALSE	20
	rs11090513	T	G	0.798	-0.016	0.175	0.013	5.00E-06	0.216	FALSE	21
	rs11230859	A	G	-0.725	0.009	0.158	0.012	4.18E-06	0.451	FALSE	21
	rs12669698	C	T	1.127	-0.033	0.255	0.017	9.73E-06	0.055	FALSE	20
	rs17145573	A	G	1.708	-0.010	0.365	0.018	2.87E-06	0.578	FALSE	22
	rs389558	T	C	-0.783	0.024	0.160	0.011	9.74E-07	0.034	FALSE	24
	rs491806	C	A	-0.948	0.011	0.211	0.014	6.92E-06	0.420	FALSE	20
	rs529324	A	G	-0.826	0.007	0.179	0.012	4.16E-06	0.574	FALSE	21
	rs7778345	G	A	0.730	-0.004	0.163	0.012	7.05E-06	0.740	FALSE	20

SNP Single nucleotide polymorphism, SE Standard error