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. Author manuscript; available in PMC: 2023 Dec 18.
Published in final edited form as: Cell. 2022 Nov 10;185(23):4409–4427.e18. doi: 10.1016/j.cell.2022.10.009

Figure 6. PRS Analysis.

Figure 6.

(A) Reproducibility in ten pairs of monozygotic (MZ) twins from MSSNG. (B) PRS distributions in MSSNG, SSC, and 1000G. (C) Comparison between individuals with ASD and non-ASD siblings. (D) Over-transmission of polygenic risk from parents to children. (E) Odds ratio of individuals with ASD to those without in each PRS decile, relative to decile 1, in MSSNG and SSC combined. (F) Pedigrees showing the PRS for each individual in two large MPX families. (G) Association between PRS and the four consensus phenotype measures.