Fig. 2.

Pre-natal exposure to BPA alters interleukin and interferon family genes. qRT-PCR results show the decreased expression of interleukin genes IL1β (a), IL 1rn (b), IL7 receptor (c), and interferon genes Irg1 (d) and Irf9 (e) in female offspring. Data represent the results obtained from four treatment groups. Mice that had been exposed to BPA in utero were subsequently treated transiently with either E2 or sesame oil as vehicle control (CTL) as adults (BPA-CTL, BPA-E2). Similarly, animals exposed to vehicle in utero subsequently received transient E2 or vehicle control stimulation as adults (CTL-E2, CTL-CTL). The data are presented as relative mRNA expression in fold change relative to vehicle-treated controls (CTL-CTL). The bars in each graph represent the mean ± S.E. of three individual experiments, each performed in triplicate. *Denotes statistical significance (p < 0.05) compared to control group (CTL-CTL)