TABLE 3.

Descriptive statistics of the mean sapanisertib PK parameters in Cycle 1 Day 1 (Day 1) and Cycle 1 Day 8 (Day 8).

	Day 1		Day 8
	Mean ± SD	Median (range)	Mean ± SD	Median (range)
C max (ng/mL)	26.1 ± 8.0	26.5 (14.9–41.8)	34.4 ± 20.9	29.4 (3.6–68.8)
T max (hr)	1.7 ± 1.1	2.0 (0.5–2.8)	1.5 ± 0.7	1.2 (0.5–2.9)
Half‐life (hr)	8.2 ± 4.9	7.1 (2.1–16.0)	24.3 ± 42.5	11.3 (2.4–144)
AUC0–24 h (hr*ng/mL)	213 ± 143	213 (61–516)	361 ± 337	182 (36.3–947)
CL (L/hr)	22.0 ± 14.2	22.0 (5.8–49.2)	23.3 ± 23.8	16.4 (3.2–82.6)