Table 2.
Parametersa | POXOL hl-PM | Abraxane® | ||||||
---|---|---|---|---|---|---|---|---|
| ||||||||
Total | Protein-bound | Encapsulated | Free | Total | Protein-bound | Encapsulated | Free | |
| ||||||||
(h) | 0.3 | 0.3 | 0.5 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
(ng/mL) | 2915.9 | 2441.9 | 292.7 | 260.3 | 2418.5 | 1931.8 | 289.5 | 206.5 |
(ng•h/mL) | 5600.1 | 4787.5 | 299.7 | 485.3 | 4864.5 | 4089.7 | 465.4 | 414.7 |
(ng•h/mL) | 5755.2 | 4936.2 | 327.7 | 498.8 | 4978.8 | 4197.9 | 489.6 | 425.8 |
CL (mL/h•kg) | 2185.3 | 2539.5 | 14785.2 | 25348.1 | 2562.7 | 3036.8 | 66001.4 | 29959.8 |
(h) | 6.4 | 6.7 | 5.5 | 6.5 | 5.8 | 5.7 | 5.5 | 5.8 |
MRT (h) | 4.2 | 4.3 | 4.5 | 4.3 | 4.1 | 4.2 | 2.7 | 4.1 |
(mL/kg) | 9530.7 | 11502.3 | 114972.3 | 114060.3 | 10597.1 | 12718.7 | 156655.9 | 118992.3 |
, time of maximum concentration; , maximum plasma concentration; , area under the curve from all time points; , area under the curve until infinite time; CL, clearance; , half life; MRT, mean residence time; , apparent volume of distribution at steady state; Each datum represents mean of 7 animals; individual animal datum can be found in Table S4.