Skip to main content
. Author manuscript; available in PMC: 2023 Dec 18.
Published in final edited form as: Biomaterials. 2021 Oct 2;278:121140. doi: 10.1016/j.biomaterials.2021.121140

Table 2.

Comparison of pharmacokinetic parameters of POXOL hl-PM and Abraxane® in rats

Parametersa POXOL hl-PM Abraxane®

Total Protein-bound Encapsulated Free Total Protein-bound Encapsulated Free

Tmax (h) 0.3 0.3 0.5 0.3 0.3 0.3 0.3 0.3
Cmax(ng/mL) 2915.9 2441.9 292.7 260.3 2418.5 1931.8 289.5 206.5
AUCall(ng•h/mL) 5600.1 4787.5 299.7 485.3 4864.5 4089.7 465.4 414.7
AUCinf(ng•h/mL) 5755.2 4936.2 327.7 498.8 4978.8 4197.9 489.6 425.8
CL (mL/h•kg) 2185.3 2539.5 14785.2 25348.1 2562.7 3036.8 66001.4 29959.8
t1/2(h) 6.4 6.7 5.5 6.5 5.8 5.7 5.5 5.8
MRT (h) 4.2 4.3 4.5 4.3 4.1 4.2 2.7 4.1
VSS(mL/kg) 9530.7 11502.3 114972.3 114060.3 10597.1 12718.7 156655.9 118992.3
a

Tmax, time of maximum concentration; Cmax, maximum plasma concentration; AUCall, area under the curve from all time points; AUCinf, area under the curve until infinite time; CL, clearance; t1/2, half life; MRT, mean residence time; VSS, apparent volume of distribution at steady state; Each datum represents mean of 7 animals; individual animal datum can be found in Table S4.