Table 3.

Comparison of pharmacokinetic parameters of POXOL hl-PM and Abraxane^® in rhesus macaque

Parametersa	POXOL hl-PM				Abraxane®				POxb
	Total	Protein-bound	Encapsulated	Free	Total	Protein-bound	Encapsulated	Free	Total
${\text{T}}_{\text{max}}$(h)	0.6	0.6	0.6	0.6	0.5	0.5	0.5	0.5	0.58
${\text{C}}_{\text{max}}$(ng/mL)	14944.0	9586.5	4301.5	1649.0	17899.5	11956.7	4127.0	1815.8	296602.6
${\text{AUC}}_{\text{all}}$(ng•h/mL)	22198.2	15072.5	4835.9	2567.6	22276.2	15801.8	3991.1	2460.5	2797225.9
${\text{AUC}}_{\text{inf}}$(ng•h/mL)	22319.6	15123.9	4918.7	2574.7	22440.2	15874.3	4032.3	2474.5	2837613.5
CL (mL/h•kg)	542.4	798.7	2440.7	4793.4	546.1	776.6	2999.6	4935.0	10.57
${\text{t}}_{1/2}$(h)	7.6	6.8	10.7	6.6	9.3	6.8	8.1	8.8	7.51
MRT (h)	4.0	4.0	3.8	3.5	4.1	4.1	4.0	4.0	9.8
${\text{V}}_{\text{SS}}$(mL/kg)	2310.9	3286.6	11890.8	17440.1	2552.4	3486.1	13896.4	21670.9	110.99

^a${\text{T}}_{\max }$, time of maximum concentration; ${\text{C}}_{\text{max}}$, maximum plasma concentration; ${\text{AUC}}_{\text{all}}$, area under the curve from all time points; ${\text{AUC}}_{\text{inf}}$, area under the curve until infinite time; CL, clearance; $\text{t}1/2$, half life; MRT, mean residence time; ${\text{V}}_{\text{SS}}$, apparent volume of distribution at steady state

^bPK parameter of POx was determined from the PET/CT study described in section Result (section 3.4). Each datum represents mean of 2 animals; individual animal datum can be found in Table S5.