Table 3.
Comparison of pharmacokinetic parameters of POXOL hl-PM and Abraxane® in rhesus macaque
Parametersa | POXOL hl-PM | Abraxane® | POxb | ||||||
---|---|---|---|---|---|---|---|---|---|
| |||||||||
Total | Protein-bound | Encapsulated | Free | Total | Protein-bound | Encapsulated | Free | Total | |
| |||||||||
(h) | 0.6 | 0.6 | 0.6 | 0.6 | 0.5 | 0.5 | 0.5 | 0.5 | 0.58 |
(ng/mL) | 14944.0 | 9586.5 | 4301.5 | 1649.0 | 17899.5 | 11956.7 | 4127.0 | 1815.8 | 296602.6 |
(ng•h/mL) | 22198.2 | 15072.5 | 4835.9 | 2567.6 | 22276.2 | 15801.8 | 3991.1 | 2460.5 | 2797225.9 |
(ng•h/mL) | 22319.6 | 15123.9 | 4918.7 | 2574.7 | 22440.2 | 15874.3 | 4032.3 | 2474.5 | 2837613.5 |
CL (mL/h•kg) | 542.4 | 798.7 | 2440.7 | 4793.4 | 546.1 | 776.6 | 2999.6 | 4935.0 | 10.57 |
(h) | 7.6 | 6.8 | 10.7 | 6.6 | 9.3 | 6.8 | 8.1 | 8.8 | 7.51 |
MRT (h) | 4.0 | 4.0 | 3.8 | 3.5 | 4.1 | 4.1 | 4.0 | 4.0 | 9.8 |
(mL/kg) | 2310.9 | 3286.6 | 11890.8 | 17440.1 | 2552.4 | 3486.1 | 13896.4 | 21670.9 | 110.99 |
, time of maximum concentration; , maximum plasma concentration; , area under the curve from all time points; , area under the curve until infinite time; CL, clearance; , half life; MRT, mean residence time; , apparent volume of distribution at steady state
PK parameter of POx was determined from the PET/CT study described in section Result (section 3.4). Each datum represents mean of 2 animals; individual animal datum can be found in Table S5.