Figure 2.

The administration of VO-OHpic during memory consolidation enhances long- but not short-term memory. A, VO-OHpic did not affect short-term memory compared with mice receiving vehicle 1 h after conditioning. B, Conversely, it significantly increased long-lasting memory at 72 h and 2 weeks, but not at 4 weeks. C, No differences were found between mice receiving vehicle or VO-OHpic during the presentation of a new tone 72 h after conditioning. D, Vehicle and VO-OHpic-injected mice did not differ from each other in the contextual freezing 48 h after learning. E, F, Bilateral intrahippocampal infusion of 10 μm VO-OHpic did not affect long-term contextual memory. Left, Arrow indicates a track needle in the dorsal hippocampus. *p < 0.05; **p < 0.01; Student's t test and 2 × 3 mixed ANOVA. Data are mean ± SEM.