Table 3.

Regression Models

Outcome	Hazard ratio	95% CI	P value
Event‐free survival (events=82)
Unadjusted Cox regression	1.53	0.99–2.36	0.06
Adjusted Cox regression	1.38	0.88–2.16	0.16
Major events (unadjusted)
Myocardial infarction (events=7)	0.96	0.21–4.28	0.96
Stroke (events=14)	1.28	0.45–3.64	0.65
Cardiovascular death (events=22)	1.09	0.47–2.53	0.84
All‐cause death (N=40)
Unadjusted Cox regression	1.78	0.95–3.33	0.07
Adjusted Cox regression	1.97	1.02–3.79	0.04
Target lesion revascularization (events=15)
Unadjusted Cox regression	0.64	0.22–1.87	0.41
Adjusted Cox regression	0.32	0.11–0.93	0.04

Bleeding events (events=116)	Odds ratio	95% CI	P value
Unadjusted logistic regression	1.32	0.87–2.00	0.19
Adjusted logistic regression	1.26	0.80–1.98	0.31

All displayed results represent the hazard or odds of the outcome at 12 months for complex PCI vs noncomplex PCI (reference). PCI indicates percutaneous coronary intervention.

After forward selection, the adjusted regressions included the following covariates:

1. Event‐free survival: age, severe valvular disease, chronic kidney disease, peripheral artery disease, alcohol use disorder, chronic obstructive pulmonary disease, frailty score, full guideline‐directed medical therapy, triple therapy, dual‐antiplatelet therapy, anticoagulation
2. All‐cause death: severe valvular disease, heart failure, dialysis, history of gastrointestinal bleeding, chronic obstructive pulmonary disease, glycoprotein IIb/IIIa inhibitor
3. Target lesion revascularization: age, race, hyperlipidemia, heart failure, prior cerebrovascular accident, anemia, frailty score, intravascular imaging
4. Bleeding events: age, hypertension, severe valvular disease, alcohol use disorder, chronic obstructive pulmonary disease, history of gastrointestinal bleeding, full guideline‐directed medical therapy, anticoagulation, bivalirudin, intravascular imaging