Table 6.
Associations Between Serial LE8 Groups and Incidence of CVD and Death After Examination Cycle 6
| CVD incidence | No. events/No. at risk | HR (95% CI) | P value | HR (95% CI)* | P value* | No. events/No. at risk† | HR (95% CI)† | P value† |
|---|---|---|---|---|---|---|---|---|
| CVD | All‐cause mortality | |||||||
| LE8 score groups | Fine‐gray models | |||||||
| High‐high | 73/488 (15) | Referent | … | Referent | … | 112/488 (23) | Referent | … |
| High‐low | 57/209 (27) | 1.84 (1.30–2.60) | 0.001 | 1.79 (1.27–2.52) | 0.001 | 60/209 (29) | 1.15 (0.84–1.57) | 0.40 |
| Low‐high | 47/144 (33) | 2.31 (1.59–3.34) | <0.001 | 2.14 (1.47–3.11) | <0.001 | 40/144 (28) | 1.16 (0.80–1.67) | 0.43 |
| Low‐low | 134/370 (36) | 2.34 (1.75–3.13) | <0.001 | 2.23 (1.67–2.99) | <0.001 | 152/370 (41) | 1.45 (1.13–1.85) | 0.003 |
High, above median LE8 score; low, below median LE8 score. Median examination 2 LE8 score=69, and median examination 6 LE8 score=66. CVD indicates cardiovascular disease; HR, hazard ratio; and LE8, Life's Essential 8.
*
Fine‐Gray models with death as a competing risk.
†
Mortality models.