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. Author manuscript; available in PMC: 2023 Dec 18.
Published in final edited form as: Cell Rep. 2023 Oct 28;42(11):113345. doi: 10.1016/j.celrep.2023.113345

Figure 1. Microbially experienced CoH mice demonstrate increased resistance against systemic UPEC-induced sepsis.

Figure 1.

Female SPF and CoH mice were infected with 4 × 107 colony forming units (CFUs) of uropathogenic E. coli (UPEC) intravenously.

(A) Survival at the indicated days post-infection.

(B) Bacterial CFU per 100 μL of blood or gram of spleen, liver, and kidney tissue of SPF and CoH mice 24 h following infection. *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.005 as determined by log rank test in (A) or nonparametric Mann-Whitney test in (B). Data in (A) were combined from two experiments lasting 5–7 days using a total of 14–18 mice per group. Data in (B) are representative from three experiments using 4–5 mice per group, where each symbol represents a mouse and bars indicate means with SEM. Dashed line in (B) indicates limit of detection of the assay.