Table 1.
Patient demographics and clinical characteristics at presentation.
| IgAN | IgAV adults | IgAV pediatrics |
P value IgAV adults, IgAN |
P value IgAV adults, pediatrics |
Overall P value |
|
|---|---|---|---|---|---|---|
| N | 45 | 60 | 60 | |||
| Age (years) | 45.1 ± 15.7 (19.1–77.3) |
53.1 ± 17.4 (18.7–88.2) |
7.28 ± 3.5 (2.95–17.2) |
.02 | N/A | N/A |
| Gender | ||||||
| Male | 35 (77.8%) | 25 (41.7%) | 33 (55.0%) | .001 | .14 | .001 |
| Female | 10 (22.2%) | 35 (58.3%) | 27 (45.0%) | |||
| Ethnic group | ||||||
| Jewish | 12 (26.7%) | 26 (43.3%) | 21 (35.0%) | .08 | .35 | .21 |
| Arab | 33 (73.3%) | 34 (56.7%) | 39 (65.0%) | |||
| BMI (kg/m2) | 27.17 ± 4.0139 (16.9–35.7) |
33.16 ± 6.9551 (19.8–55.0) |
17.54 ± 4.2559 (13–35) |
.001 | N/A | N/A |
| Obesity (BMI > 30) | 9/39 (23.1%) | 34/51 (66.7%) | N/A | .001 | N/A | N/A |
| Smoking | 19/44 (43.2%) | 21 (35.0%) | N/A | .40 | N/A | N/A |
| Co-morbidities | ||||||
| Diabetes Mellitus type II | 11 (24.4%) | 26 (43.3%) | 0 (0.0) | .05 | N/A | N/A |
| Ischemic heart disease | 2 (4.4%) | 11 (18.3%) | N/A | .03 | N/A | N/A |
| Malignancy | 0 (0%) | 4 (6.7%) | 0 (0%) | 0.13 | N/A | N/A |
| Preceding infection | 0/44 (0%) | 4 (6.7%) | 8/58 (13.8%) | .22 | .02 | .003 |
| Positive culture Probable |
6/44 (13.6%) | 8 (13.3%) | 18/58 (31.0%) | |||
| Medications | ||||||
| Antibiotics | 4 (8.9%) | 11 (18.3%) | 15 (25.0%) | .26 | .38 | .11 |
| ACEI/ARB | 18 (40.0%) | 19 (31.7%) | N/A | .38 | N/A | N/A |
| Beta blockers | 10 (22.2%) | 16 (26.7%) | N/A | .60 | N/A | N/A |
| Antidiabetic drugs | 5 (11.1%) | 19 (31.7%) | N/A | .01 | N/A | N/A |
| Corticosteroids | 2 (4.4%) | 2 (3.3%) | N/A | >.99 | >.99 | 0.70 |
| Immunosuppressants | 1 (2.2%) | 0 (0.0%) | N/A | .43 | N/A | N/A |
| PPI or H2B | 7 (15.6%) | 22 (36.7%) | N/A | .02 | N/A | N/A |
| Diuretics | 2 (4.4%) | 19 (31.7%) | N/A | .001 | N/A | N/A |
Bold values represents significant P-values. Superscript numbers are number of patients with available information.
ACEI = angiotensin-converting enzyme inhibitor, ARB = angiotensin II receptor blocker, BMI = body mass index, H2B = histamine-2 receptor blocker, IgAN = IgA nephropathy, IgAV = IgA vasculitis, N = number of patients, N/A = not available, PPI = proton-pump inhibitor.