Table 4.
Outcomes and treatments of adults with IgAN and IgAV during 1 year follow up and long term mortality.
| IgAN | IgAV adults | P value | |
|---|---|---|---|
| N | 45 | 42 | |
| Clinical manifestations | |||
| Palpable purpura | 0 (0.0%) | 1/31 (3.2%) | .44 |
| Abdominal pain | 1/40 (2.5%) | 2/31 (6.5%) | .41 |
| Arthritis/Arthralgia | 1/40 (2.5%) | 0 (0.0%) | >.99 |
| Renal involvement | |||
| Serum creatinine (mg/dL) | 2.002 ± 2.275 42 (0.54–12.67) |
1.100 ± 1.313 40 (0.46–8.47) |
<.001 |
| Hematuria | 16/30 (53.3%) | 6/16 (37.5%) | .30 |
| Leukocyturia | 1/31 (3.2%) | 3/16 (18.8%) | .11 |
| Dipstick proteinuria | 23/35 (65.7%) | 6/17 (35.2%) | .02 |
| Proteinuria > 300 (mg/d) or Urine P/C > 300 (mg/g) | 31/36 (86.1%) | 6/14 (42.8%) | .002 |
| Proteinuria (mg/24h) | 1375.9 ± 2858.0 32 (113.1–5337.7) |
1478.9 ± 2446.0 7 (767.8; 36–6920) |
.30 |
| Urine P/C ratio (mg/g) | 938.0 ± 827.5 27 (44.1–3596.3) |
1196.2 ± 2858.0 9 (58.9–8781.0) |
.03 |
| Treatment | |||
| NSAID | 0 (0.0%) | 0/26 (0.0%) | N/A |
| Prednisone 20 mg | 8/40 (20.0%) | 0/26 (0.0%) | .02 |
| Prednisone 10 mg | 3/40 (7.5%) | 0/26 (0.0%) | .27 |
| Prednisone 1 mg | 3/40 (7.5%) | 1/26 (3.8%) | >.99 |
| Any dose prednisone | 14/40 (35.0%) | 1/26 (3.8%) | .003 |
| Cyclophosphamide | 0/40 (0.0%) | 0/26 (0.0%) | N/A |
| Cyclosporine | 2/40 (5.0%) | 0/26 (0.0%) | .52 |
| Imuran | 1/40 (2.5%) | 2/26 (7.7%) | .56 |
| ACEi/ARB | 31/40 (77.5%) | 4/26 (15.4%) | <.001 |
| Colchicine | 0 (0.0%) | 1/25 (4.0%) | >.99 |
| Late dialysis | 4/42 (9.5%) | 2/39 (5.1%) | .68 |
| Mortality | |||
| 1-year mortality | 0 (0%) | 7/60 (11.7%) | .02 |
| Long-term deaths | 3/45 (6.67%) | 14/60 (23.33%) | |
| COVID19 | 1 | – | |
| Sepsis | 1 | 4 | |
| Cancer | – | 2 | |
| Cardiovascular | 1 | 6 | |
| Other | – | 2 | |
Bold values represents significant P-values. Superscript numbers are number of patients with available information.
ACEi = angiotensin-converting enzyme inhibitor, ARB = angiotensin II receptor blocker, IgAN = IgA nephropathy, IgAV = IgA vasculitis, N = number of patients, N/A = not available, NSAID = non-steroidal anti-inflammatory drug, Urine P/C = urine protein to urine creatinine ratio.