Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 15;8(1):e0348. doi: 10.1097/HC9.0000000000000348

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Neutrophils and NETs in PHLF. (A) Experimental scheme. Liver biopsies were collected before (Pre) and 2 hours after (Reg) PHx from 25 patients without PHLF and 10 patients with PHLF. (B, C) Immunofluorescence staining of DNA (Hoechst33342), neutrophils (CD66b), and NETs (CitH3) of 35 hepatic resection biopsies taken before resection (Pre) and 2 hours after resection (Reg). Pictures are representative of (B) 25 patients without PHLF or (C) 10 patients with PHLF. (D, E) Relative quantification of (D) neutrophils and (E) NETs in patients with PHLF or without PHLF (two-way ANOVA with Tukey correction for multiple comparisons: *p<0.05, **p<0.01). Regeneration-induced effects depicted as difference after-before resection (∆Reg-Pre) (unpaired t test: **p <0.01). Abbreviations: CitH3, citrullinated histone H3; MPO, myeloperoxidase; NET, neutrophil extracellular trap; PHLF, posthepatectomy liver failure; PHx, partial hepatectomy.