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. 2023 Dec 15;8(1):e0343. doi: 10.1097/HC9.0000000000000343

FIGURE 2.

FIGURE 2

The molecular mechanism of nuclear receptor regulation on the rate-limiting enzyme CYP7a1 in bile acid synthesis. The inner ring represents the key nuclear receptor. The intermediate ring represents the factor or pathway that the nuclear receptor acts on. The outer ring is a model graph. Abbreviations: CYP7A1, cytochrome P450; FXR, farnesoid X receptor; HNF4α, hepatocyte nuclear factor 4 alpha; LXR, liver X receptor; PPAR, peroxisome proliferator-activated receptor; retinoid X receptor; SHP, small heterodimer partner.