Skip to main content
. Author manuscript; available in PMC: 2024 May 10.
Published in final edited form as: ACS Appl Mater Interfaces. 2023 Apr 28;15(18):21877–21892. doi: 10.1021/acsami.3c01501

Figure 8.

Figure 8.

In vivo intracellular delivery of K27 protein in an HTVI-induced mouse model of hepatocellular carcinoma. (A) Representative IVIS images of murine organs after IV administration of 3 mg/kg K27-D30-HiBiT protein either free (left) or delivered via LNPs (right). (B) Quantification of luminescent signal—normalized to background—shows significant increase in signal when protein is delivered via LNPs, indicating intracellular delivery of protein in the liver. n ≧ 3; **: p <0.01. (C) IVIS images of livers after IV administration of free K27-D30-HiBiT protein (top), K27-D30-HiBiT LNPs (middle), or PBS (bottom).