Behavioural and systemic biomarker outcomes. Effects of injury and post-injury sleep disturbance (SD), exercise (Ex) or both (SD+Ex) on: (A) forepaw mechanical sensitivity to 1 cN or 4 cN monofilament testing, (B) reflexive grip strength, (D–E) serum levels of BDNF and estradiol, and (F) whole blood levels of white blood cells. Post-int. = post-intervention. *p < 0.05, **p < 0.01, between groups as shown.