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. 2023 Oct 7;31(12):3545–3563. doi: 10.1016/j.ymthe.2023.10.003

Figure 8.

Figure 8

Striatal synaptic contacts located outside the stem cell implantation zone

(A) An L-NT is making either an asymmetrical synaptic contact (black arrow) or a symmetrical contact (white arrow) with an underlying hNSC-negative/unlabeled dendritic spine (U-SP) (note the darkened DAB reaction product within the nerve terminals). The hNSC-L-NTs originate from the implanted stem cells, while the unlabeled dendritic spines originate from the host striatum. (B) U-NTs are making either an asymmetrical synaptic contact (white arrow) or a symmetrical contact (black arrow) with an underlying hNSC-positive/L-DEN (note the darkened DAB reaction product within the dendrite). The hNSC-L-DEN originates from the implanted stem cells, while the U-NTs originate from the host striatum. (C) U-NT making an asymmetrical synaptic contact (arrow) with an underlying hNSC-positive/L-DEND (note the darkened DAB reaction product within the dendrite). The hNSC-L-DEN originates from the implanted stem cells, while the U-NT originates from the host striatum. (D) An L-NT is making a symmetrical synaptic contact (black arrow) with an underlying hNSC-positive/ L-SP (note the darkened DAB reaction product within the nerve terminal and spine). The hNSC-L-NT and dendritic spine originate from the implanted stem cells.